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KMID : 1059519860300030320
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Journal of the Korean Chemical Society
1986 Volume.30 No. 3 p.320 ~ p.326
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Synthesis and Characterization of Pd(II) Complexes with Adenine, Uracil, Cytosine and Malonate Ligands
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Oh Sang-Oh
Mo Seong-Jong
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Abstract
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The antitumor properities of metal are not limited to Pt(Ⅱ) complexes. Recently, it was reported that some Pt(Ⅱ) and Pd(Ⅱ) complexes with sulfur and nitrogen ligands had potential antitumor reactivity. Pt(Ⅱ) complexes is toxic drug for anticancer. Therefore, the complexes of Pd(Ⅱ) with adenine, uracil, cytosine and malonate ligands are interesting for anticancer drug. We synthesized new palladium complexes containing nucleosides. The reactions of Pd(Ⅱ) with adenine, uracil, cytosine and malonate ligands have been studied in aqueous solutions. The complexes isolated from these reactions have the following formulas; [Pd(en)(C5H5N5)2](NO3)2, [Pd(en)(C4H3N2O2)Cl], [Pd(en)(C3H2O4] and [Pd(en)(C4H5N3O)2](NO3)2·(C4H5N3O). The compounds have been identified by elemental analysis, mass spectra, infrared spectra and electronic spectra.
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KEYWORD
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